Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

IMPACT OF TREATMENT ON MEASURES OF IMMUNE INFLAMMATION ACTIVITY AND STRUCTURAL-FUNCTIONAL PROPERTIES OF VASCULATURE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Knyazeva L.I. 1 Okrachkova I.V. 1 Bondyreva A.V. 1 Knyazeva L.A. 1
1 Kursk State Medical University, Kursk
This article contains the results of research of serum levels of proinflammatory cytokines (IL-1в, IL-6, TNF-б), leptin, vasculature rigidity and elasticity measures in 60 patients with type 2 diabetes mellitus with obesity and 32 patients with type 2 diabetes mellitus and BMI < 25 kg/m2. The control group consisted of 24 persons without disorders of carbohydrate metabolism and obesity. Proinflammatory cytokinemia, hyperleptinemia, vasculature elasticity decrease and rigidity increase were determined in patients with type 2 diabetes mellitus, reaching their maximum in patients with obesity. It was found out that serum levels of IL-1в, IL-6, TNF-б and leptin were increased, while measures of structural-functional properties of arterial vasculature were changed in patients with type 2 diabetes mellitus with obesity. It was determined, that in addition to lipid-lowering effect, fenofibrate also has pleiotropic anti-inflammatory and vasoprotective activity.
proinflammatory cytokines
leptin
structural-functional properties of the vessel wall
fenofibrate
diabetes mellitus
1. Algoritmy specializirovannoj medicinskoj pomoschi bol’nym saharnym diabetom. Pod. red. I.I. Dedova., M.V. Shestakovoj. M., 2009. vypusk 4. 03 р.
2. Dedov I.I. Saharnyj diabet v Rossii: problemy i resheniya / I.I. Dedov, M.V. Shestakova, Yu.I. Suncov // M., 2008. рр. 3–6.
3. Ketlinskij S.A., Simbircev A.S. Citokiny. SPb, 2008. 552 р.
4. Dinamika pokazatelej uprugosti sosudistoj stenki u bol’nyh serdechnoj nedostatochnost’yu, perenesshih ostryj infarkt miokarda / S.V. Nedogoda, O.V. Ilyuhin, V.V. Ivanenko i dr. // Zhurnal “Serdechnaya nedostatochnost’”. t. 4, no. 2. 2009. pp. 95–98.
5. Klebanova E.M. Gormony zhirovoj tkani i ih rol’ v patogeneza saharnogo diabeta 2 tipa / E.M. Klebanova, M.I. Balabolkina // Lech. vrach. 2010. no. 11. pp. 12–16.
6. Kobalava Zh.D. Vysokoe sistolicheskoe davlenie: akcent na elasticheskie svojstva arterij / Zh.D. Kobalava, Yu.V. Kotovskaya, B.A. Barkova, S.V. Villevayace // Kardiovask. terapiya i profilakt. 2006. no. 5. pp. 10–16.
7. Prasolov A.V. Vliyanie bisoprolola na immunnye markery kardiovaskulyarnogo riska, elasticheskie svojstva sosudistoj stenki i variabel’nosti ritma serdca u bol’nyh stabil’noj stenokardiej napryazheniya / A.V. Prasolov // Kurskij nauchno-prakticheskij vestnik «Chelovek i ego zdorov’e». 2010. no. 1. pp. 53–59.
8. Ahima R.S. Leptin / R.S. Ahima //Ann Rev Physiol. 2000, Vol. 62. рр. 413–417.
9. Shaw J.E., Sicree R.A., Zimmet P.Z. Diabetes / J.E. Shaw, R.A. Sicree, P.Z. Zimmet //Res Clin Pract. 2010. Vol. 87. рр. 4–14.

Рецензенты:

Ефремова О.А., д.м.н., зав. кафедрой внутренних болезней № 2 ФГАОУ ВПО «Белгородский государственный национальный исследовательский университет», г. Белгород;

Вишневский В.И., д.м.н., профессор, зав. кафедрой внутренних болезней медицинского института ФГБОУ ВПО «Орловский государственный университет», г. Орел.

Работа поступила в редакцию 24.07.2012.