Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
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PROSPECTS OF PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED PREECLAMPSIA IN EXPERIMENT BY MEANS OF INHIBITOR OF ARGINASE L-NORVALINE AND OF INHIBITOR OF PHOSPHODIESTERASE 5 TADALAFIL

Polyanskаya O.S. 1
1 National Research University Belgorod State University, Belgorod
L-NAME administration in pregnant rats leads to blockade of endothelial NO-sintasa and to pathological changes similar to preeclampsy in women. Blood pressure elevation, gestational proteinuria, placenta microcirculation impairing, vascular tone and NO-produse function dysregulation were obcerved. Pharmacological agent increasing NO activity administration inhibitor of arginase L-norvaline and of inhibitor of phosphodiesterase 5 tadalafil. It speaks impact on a pharmacological way of L-arginin – TsGMF that the endoteliya leads finally to simplification of vazodilatiruyushchy mechanisms and function normalization. Recent studies are background for future investigations and clinical adoption or broaden their indications.
rats
preeclampsy
L-NAME
treatment
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Рецензенты: 

Иванова О.Ю., д.м.н., доцент кафедры акушерства и гинекологии ГБОУ ВПО «Курский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. Курск;

Рыбников В.Н., д.м.н., доцент кафедры акушерства и гинекологии ГБОУ ВПО «Курский государственный медицинский университет» Министерства здравоохранения и социального развития РФ, г. Курск.

Работа поступила в редакцию 21.09.2012.