Scientific journal
Fundamental research
ISSN 1812-7339
"Перечень" ВАК
ИФ РИНЦ = 1,674

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THE SYSTEM OF IL-6 AS A RISK FACTOR OF URGENT CRITICAL CONDITION DEVELOPMENT IN PATIENTS WITH ESSENTIAL HYPERTENSION

Radaeva O.A. 1 Novikova L.V. 2
1 Mordovian State N.P. Ogariov University
2 Mordovian State N.P. Ogariov University, Saransk
Objectives. We tested the hypothesis that serum interleukin-6 (IL-6) and its soluble receptor (sIL-6R) levels predict cardiovascular events in patients with in essential hypertension (ЕAН). Methods. We prospectively studied in 120 patients with II stage ЕAН (68 men and 52 women), 49,5 ± 2,8 years of age. Serum IL-6 and sIL-6R levels were measured with an enzyme-linked immunosorbent assay. Results. During a median 5-year follow-up, 32 cardiovascular events occurred. Both total IL-6 and sIL-6R levels were direct associated with the risk of cardiovascular events. Patients in the 2 higher quartiles of IL-6 (≥ 18,2 pg/ml) had an increase risk of cardiovascular events compared with patients in the 2 lower quartiles (relative risk: 7,95 % confidence interval: 2,6 to 13,3). Patients in the 2 higher quartiles of IL-6 (≥ 18,2 pg/ml) had an increase risk of cardiovascular events compared with patients in the 2 lower quartiles (relative risk: 7,95 % confidence interval 2,6 to 13,3). Compared with the third quartile of serum sIL-6R levels (1739–1890 pg/ml), the relative risks the first-ever stroke and the myocardial infarction for patients with II stage ЕAН were as follows fourth quartile (1891 – 2218 pg /ml), 6 (95 % confidence interval, 2,7–10). Conclusions. High serum interleukin-6 (IL-6) and its soluble receptor (sIL-6R) predicted a increased 5-year risk of cardiovascular events in patients with ЕAН.
essential hypertension
interleukin-6
soluble receptor
myocardial infarction
blood stroke
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Рецензенты:

Потатуркина-Нестерова Н.И., д.м.н., профессор, зав. курсом микробиологии кафедры общей и клинической фармакологии, ФВПОУ ВПО «Ульяновский государственный университет», г. Ульяновск;

Карзакова Л.М., д.м.н., профессор, заведующая кафедрой госпитальной терапии № 2 медицинского факультета, ФВПОУ ВПО «Чувашский государственный университет имени И.Н. Ульянова», г. Чебоксары.